Monthly Newsletter for November 2014
Agilent is Exiting the NMR Business
On October 14th 2014, Agilent Technologies made the following announcement to customers:
Dear Agilent Customer,
As you are a valued customer, we want to let you know that in response to certain market conditions, Agilent has made the strategic decision to close its NMR (Nuclear Magnetic Resonance) business.
Effective immediately, Agilent will no longer be accepting orders for NMR systems. We will honor our existing contractual commitments to deliver open orders and fulfill support obligations. Agilent will continue to provide support for 7 years after product obsolescence, information about our ongoing support offerings can be found here.
We value your partnership with Agilent and we will do our best to minimize any inconvenience or disruption to your business.
For further information please contact us at pdl-nmr@agilent.com.
Thank you for your ongoing commitment to Agilent.
Sincerely,
Regina Schuck,
VP and GM, Research Products Division, Agilent Technologies
This business closure and layoff of over 300 people marks the end of Varian, Inc. which Agilent acquired in 2010 for approximately $1.5 billion. Varian invented the commercial NMR spectrometer as well as Fourier transform spectroscopy, and its absence leaves the current NMR spectrometer market a virtual monopoly for Bruker Biospin. Agilent is providing no indication that it intends to spin-off or sell-off its NMR assets, instead opting to book a financial loss and close the business. While this decision will have no immediate impact on CBIC operations, it is a disappointing development for the NMR community as well as for those who use NMR spectroscopy.
We will provide updates if any new information becomes available regarding this decision.
A Message from Yale West Campus
Flow Cytometry: New m-cherry Laser with the following laser lines installed on the BD FACS Aria.
- 670-nm: PE-Cy5
- 610-nm PE-Texas Red
- 585-nm PE
Please contact Ken.Nelson@Yale.edu for information and training.
Have you ever wanted to find out how the cores at West Campus can help your research? Join us for Pizza in the WC CC and find out. Tours of cores, and 1:1 discussions will follow the talks. Participating Cores include Yale Center for Genome Analysis, Yale Center Molecular Diversity, Research Support Services and West Campus Analytical Core. See flyer attached.
Recent Publications from Yale's Chemistry Department
The CBIC strives to support the research throughout Yale University. In that spirit, we would like to highlight recent publications from the Chemistry Department. Congratulations to all the authors! We look forward to serving your instrumentation needs in future manuscript preparations.
Structural Changes in the Oxygen-Evolving Complex of Photosystem II Induced by the S1 to S2 Transition: A Combined XRD and QM/MM Study
Mikhail Askerka, Jimin Wang, Gary W. Brudvig, and Victor S. Batista
Photoelectrochemical Hole Injection Revealed in Polyoxotitanate Nanocrystals Functionalized with Organic Adsorbates
Christian F. A. Negre, Karin J. Young, Ma. Belen Oviedo, Laura J. Allen, Cristian G. Sanchez, Katarzyna N. Jarzembska, Jason B. Benedict, Robert H. Crabtree, Philip Coppens, Gary W. Brudvig, and Victor Salvador Batista
Looking at LncRNAs with the Ribozyme Toolkit
Anna Marie Pyle
Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome
Yury S. Polikanov, Ilya A. Osterman, Teresa Szal, Vadim N. Tashlitsky, Marina V. Serebryakova, Pavel Kusochek, David Bulkley, Irina A. Malanicheva, Tatyana A. Efimenko, Olga V. Efremenkova, Andrey L. Konevega, Karen J. Shaw, Alexey A. Bogdanov, Marina V. Rodnina, Olga A. Dontsova, Alexander S. Mankin, Thomas A. Steitz, and Petr V. Sergiev
Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA
Yury S. Polikanov, Teresa Szal, Fuyan Jiang, Pulkit Gupta, Ryoichi Matsuda, Masataka Shiozuka, Thomas A. Steitz, Nora Vázquez-Laslop, and Alexander S. Mankin
Remote Conformational Control of a Molecular Switch via Methylation and Deprotonation
Peter C. Knipe, Ian M. Jones, Sam Thompson, and Andrew D. Hamilton
Designed Phosphoprotein Recognition in Escherichia coli
Nicholas Sawyer, Brandon M. Gassaway, Adrian D. Haimovich, Farren J. Isaacs, Jesse Rinehart, and Lynne Regan
Positive Allostery in Metal Ion Binding by a Cooperatively Folded ß-Peptide Bundle
Jonathan P. Miller, Michael S. Melicher, and Alanna Schepartz
Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors
Georgios Pantouris, Deepa Rajasekaran, Alvaro Baeza Garcia, Victor G. Ruiz, Lin Leng, William L. Jorgensen, Richard Bucala, and Elias J. Lolis
Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers
Won-Gil Lee, Kathleen M. Frey, Ricardo Gallardo-Macias, Krasimir A. Spasov, Mariela Bollini, Karen S. Anderson, and William L. Jorgensen
Pharmacological Targeting of the Pseudokinase Her3
Ting Xie, Sang Min Lim, Kenneth D Westover, Michael E Dodge, Dalia Ercan, Scott B. Ficarro, Durga Udayakumar, Deepak Gurbani, Hyun Seop Tae, Steven M Riddle, Taebo Sim, Jarrod AMarto, Pasi A Jänne, Craig M Crews, and Nathanael S. Gray
Role of HF in Oxygen Removal from Carbon Nanotubes: Implications for High Performance Carbon Electronics
Xiaokai Li, Jing-Shun Huang, Siamak Nejati, Lyndsey McMillon, Su Huang, Chinedum O. Osuji, Nilay Hazari, and Andre D. Taylor
Interferon Production Using Short RNA Duplexes
Anna Marie Pyle, Andrew Kohlway, and Dahai Luo
Site-Selective Functionalization of Glycopeptide Antibiotics
Tejaskumar P. Pathak and Scott J. Miller
Updates
There are a number of ways you can stay updated about what is happening in the CBIC -- If you have any questions, you should always feel free to ask any of the CBIC staff, either in person or via email. If you are not on our email list, you can subscribe at https://messages.yale.edu/Subscribe/Groups/AllGroups. You can also visit http://cbic.yale.edu or follow us on Twitter @yalecbic.