Monthly Newsletter for April 2015
CBIC Survey Closing
Thank you to everyone who participated in our CBIC Feedback Survey. We are closing the survey at midnight tonight (April 2nd). So, if you still haven't had a chance to provide your much appreciated feedback to us, please do so today at:
CBIC Instrument Updates
After several months of ongoing problems with nearly all of our X-ray diffraction instruments, we are pleased to note that these instruments ran smoothly throughout the month of March. The additional cold-streams we recently added have also been working well, improving the performance of our instruments -- especially the SCX-Mini. Moving forward, we are hopeful that the X-ray instruments will continue to run as well as they have been recently.
To help solve the ongoing sample changer problems, we have modified all the spinners for the A400c. This has indeed made the sample changer more reliable, by allowing a sensor in the magnet to more accurately detect the presence or absence of a sample. In the future, we plan to modify all of our spinners, except those used on the A600a. This instrument's sample changer has a different type of sensor, and so we ask that A600a patrons continue to use only the spinners designated for this instrument (marked "A600a only" on the spinner). An additional reminder to users of the A600a: Please be careful when loading your samples! We have had instances of samples being loaded into the location already occupied by a sample in the magnet -- in the best case, this mistake will halt the automation run, in the worst case this could break an NMR tube.
Finally, the A600a, along with many of our other instruments, was temporarily knocked offline by a brief power outage last Monday. All of the instruments are now back online. The power failure also took out two hard drives which have since been replaced. We have recovered most of the data and are working to recover the rest.
As per the planned trade in TA Instruments has removed the old MicroCal ITC 200. Patrons are encouraged to use the new NanoITC (located at the same table where the MicroCal used to be). The new instrument will provide comparable if not better data than the MicoCal. Those who did not attend the initial training session run by TA instruments upon the NanoITC's installation should get in touch with the CBIC staff before using the instrument. Feel free to use our Contact Us form.
Recent Publications from Yale's Chemistry Department
The CBIC strives to support the research throughout Yale University. In that spirit, we would like to highlight recent publications from the Chemistry Department. Congratulations to all the authors! We look forward to serving your instrumentation needs in future manuscript preparations.
Pre-drilling background groundwater quality in the Deep River Triassic Basin of central North Carolina, USA
Adrian Down, Kathrin Schreglmann, Desiree L. Plata, Martin Elsner, Nathaniel R. Warner, Avner Vengosh, Katie Moore, Drew Coleman, Robert B. Jackson
Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APLB and APL1C and Their Interaction with LRIM1
Marni Williams, Brady J. Summers, Richard H. G. Baxter
Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization
Kristina Oresic Bender, Leslie Ofori, Wouter A. van der Linden, Elliot D. Mock, Gopal K. Datta, Somenath Chowdhury, Hao Li, Ehud Segal, Mateo Sanchez Lopez, Jonathan A. Ellman, Carl G. Figdo , Matthew Bogyo, and Martijn Verdoes
Identification of Multiple Structurally Distinct, Nonpeptidic Small Molecule Inhibitors of Protein Arginine Deiminase 3 Using a Substrate-Based Fragment Method
Haya Jamali, Hasan A. Khan, Joseph R. Stringer, Somenath Chowdhury, and Jonathan A. Ellman
Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation
Oleg V. Kulikov, Sunil Kumar, Mazin Magzoub, Peter C. Knipe, Ishu Saraogi, Sam Thompson, Andrew D. Miranker, Andrew D. Hamilton
Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics
Sunil Kumar, Diana E. Schlamadinger, Mark A. Brown, Joanna M. Dunn, Brandon Mercado, James A. Hebda, Ishu Saraogi, Elizabeth Rhoades, Andrew D. Hamilton, Andrew D. Miranker
Base-Free Methanol Dehydrogenation Using a Pincer-Supported Iron Compound and Lewis Acid Co-catalyst
Elizabeth A. Bielinski, Moritz Förster, Yuanyuan Zhang, Wesley H. Bernskoetter, Nilay Hazari, and Max C. Holthausen
Medium Effects Are as Important as Catalyst Design for Selectivity in Electrocatalytic Oxygen Reduction by Iron–Porphyrin Complexes
Matthew L. Rigsby, Derek J. Wasylenko, Michael L. Pegis, and James M. Mayer
Moving Protons and Electrons in Biomimetic Systems
Jeffrey J. Warren and James M. Mayer
A molecular catalyst for water oxidation that binds to metal oxide surfaces
Sheehan S.W., Thomsen J.M., Hintermair U., Crabtree R.H., Brudvig G.W., Schmuttenmaer C.A.
Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly
Polikanov YS, Melnikov SV, Söll D, Steitz TA
Photoinduced Water Oxidation at the Aqueous GaN (101̅0) Interface: Deprotonation Kinetics of the First Proton-Coupled Electron-Transfer Step
Mehmed Z. Ertem, Neerav Kharche, Victor S. Batista, Mark S. Hybertsen, John C. Tully, and James T. Muckerman
The Effect of Remote Aryl Substituents on the Conformational Equilibria of 2,2-Diaryl-1,3-dioxanes: Importance of Electrostatic Interactions
William F Bailey, Kyle M Lambert, Kenneth B Wiberg, and Brandon Q Mercado
There are a number of ways you can stay updated about what is happening in the CBIC -- If you have any questions, you should always feel free to ask any of the CBIC staff, either in person or via email. If you are not on our email list, you can click here to subscribe. You can also visit us at cbic.yale.edu or follow us on Twitter @yalecbic.